Dataset details
The PPFE Cell Atlas
Published paper
The pleuroparenchymal fibroelastosis atlas reveals aberrant cell states and their zonation as an alternate roadmap to lung fibrosis
Authors
Jannik Ruwisch, Aurélie Cazes, Lena M Leiber, Raphael Borie, Lavinia Neubert, Christian Leonard, Vincent Thomas de Montpréville, Adam Szmul, Farah Moussa, Stijn E Verleden, Svenja Gaedcke, Jan Hegermann, Jan Fuge, Matthias Ballmaier, Jan C Kamp, Mark Greer, Peter Braubach, Christopher Werlein, Fabius Ius, Theresa Graalmann, Kalil Aburahma, Laurens J De Sadeleer, Ryoko Egashira, Maximilian Ackermann, Daisuke Yamada, Marius M Hoeper, Christine Falk, Jens Gottlieb, Herbert B Schiller, Bart Vanaudenaerde, Benjamin Seeliger, Marie Pierre Debray, Jean Francois Bernaudin, Lars Knudsen, Emmanuel Bergot, Joseph Jacob, Hervé Mal, Danny Jonigk, Sabine Dettmer, Pierre Mordant, Antje Prasse, Elie Fadel, Wim A Wuyts, Bruno Crestani, Naftali Kaminski, Aurélien Justet, Jonas C Schupp
DOI
10.1101/2025.07.06.663336
Description
We present the first snRNAseq atlas of PPFE’s cellular and structural landscape based on a European multinational cohort. 24 PPFE patients were female (60.0%), while 34 were non-smokers (85.0%). 519,920 nuclear transcriptomes from PPFE and IPF patients, and controls were profiled.